Magnesium
Magnesium, a mineral. Mg²⁺ stabilises ATP (Mg-ATP is the catalytically active form) and serves as a cofactor for 300+ enzymes including kinases, phosphatases, and…
Mg²⁺ stabilises ATP (Mg-ATP is the catalytically active form) and serves as a cofactor for 300+ enzymes including kinases, phosphatases, and glycolytic/TCA/Oxidative phosphorylation steps. Voltage-dependent block of Glutamate receptor pharmacology receptor Ca²⁺ channels drives the sleep-onset and neuroprotective effects. Required for DNA/RNA and protein synthesis. CNS penetration is form-dependent — threonate raises CSF Mg²⁺ measurably in rodent models (Slutsky 2010).
Related compounds
- Vitamin D3 — synergistic
- Calcium — caution
- Zinc — caution
- Aspartate — synergistic
- Magnesium BHB — synergistic
- Magnesium Citrate — synergistic
- Magnesium Glycinate — synergistic
- Magnesium Malate — synergistic
Sources: PMID:20152124, PMID:16548135, PMID:11550076, PMID:42091979, PMID:12775558, PMID:25287933