CDP-Choline

nucleotide · nervous · Oral · IV

CDP-Choline, a nucleotide. Hydrolysed in the gut to cytidine + choline — both absorbed and each crosses BBB (cytidine converts to uridine in circulation). Reassembled…

Hydrolysed in the gut to cytidine + choline — both absorbed and each crosses BBB (cytidine converts to uridine in circulation). Reassembled intracellularly to CDP-choline, the rate-limiting substrate in the Kennedy pathway for phosphatidylcholine synthesis. Raises brain acetylcholine, dopamine, and noradrenaline levels. Largest clinical use: post-stroke cognitive rehabilitation (evidence mixed but more favourable than for alpha-GPC on stroke endpoints).

Related compounds

• Alpha-GPC — synergistic
• Uridine — synergistic
• Cytidine — synergistic

Sources: PMID:19906248, PMID:6412727, PMID:10974208