Cyanocobalamin

vitamin · nervous · immune-hematologic · Oral · Sublingual · Intramuscular

Cyanocobalamin, a vitamin. Cobalamin with a cyanide ligand at the central cobalt — must be dealkylated by cyanocobalamin reductase and reduced to… Oral half-life 6 d.

Cobalamin with a cyanide ligand at the central cobalt — must be dealkylated by cyanocobalamin reductase and reduced to cob(II)alamin before conversion to methylcobalamin (cytosol) or adenosylcobalamin (mitochondrion), the two active coenzyme forms. Oral absorption requires gastric intrinsic factor (IF) + ileal cubilin/amnionless uptake — saturable at ~1.5 mcg per dose; passive diffusion at ~1% above that.

Pharmacokinetics

• Oral — t½ 6.0 d · F 3% · Vd 42 L

Related compounds

• Methylcobalamin — synergistic
• Metformin — caution
• Adenosylcobalamin — synergistic
• Hydroxocobalamin — synergistic

Sources: PMID:18709891