Methylcobalamin
Methylcobalamin, a vitamin. Pre-activated methyl-carrying form used directly by methionine synthase (remethylation of homocysteine → methionine (see methionine sam…
Pre-activated methyl-carrying form used directly by methionine synthase (remethylation of Homocysteine → Methionine (see Methionine cycle)). Does not cover mitochondrial methylmalonyl-CoA mutase — that requires Adenosylcobalamin, which cells synthesise from reduced cobalamins. Preferred by some authors in B12 deficiency with neurologic features, though head-to-head clinical superiority over Cyanocobalamin is not established.
Related compounds
- L-Methylfolate (5-MTHF) — synergistic
- Cyanocobalamin — synergistic
- Adenosylcobalamin — synergistic
- Folic Acid — synergistic
- Hydroxocobalamin — synergistic
Sources: PMID:18709891