L-Methylfolate
L-Methylfolate, a vitamin. Active folate (see folate one carbon); methyl donor for homocysteine remethylation. Oral half-life 3 h.
Active folate (see Folate / one-carbon metabolism); methyl donor for Homocysteine remethylation.
PK: THE STORED VOLUME WAS THE SOLVER DEFAULT WEARING A CITATION. 35 L is exactly 0.5 L/kg at the seventy-kilogram reference — the value resolvePk substitutes when the field is ABSENT — and this record cited abstract states no volume at all. Removing it is NUMERICALLY A NO-OP, since the resolver now supplies the identical number; what changes is that the record stops asserting a measurement it does not have, and the defaulted-volume lint begins counting it as the open gap it is. This is the batch-11 finding running backwards: there a deletion silently became a default, here a default had silently become a datum. PK: THE STORED ABSORPTION RATE WAS THE SOLVER DEFAULT WEARING A CITATION. A ka of 1.0/h is exactly what resolvePk substitutes when the field is ABSENT, and no source on this record states one. Removing it is NUMERICALLY A NO-OP — the resolver supplies the identical number — so no curve moves; what changes is that the record stops asserting an absorption rate it never measured. This is the same shape already found on a volume of 35 L, which is likewise the default at the seventy-kilogram reference. THE WIDER DEBT IS LEFT ALONE ON PURPOSE: twelve values account for 152 of the 276 authored absorption rates, but the other eleven are NOT the default, so deleting those would move their curves rather than leave them, which is the error this audit spent a batch documenting.
Pharmacokinetics
- Oral — t½ 3 h · F 95%
Related compounds
- B12 (methylcobalamin) — synergistic
- SAMe — synergistic
- Folic Acid — synergistic
Sources: PMID:24494987, PMID:22909145