Folate / one-carbon metabolism

biosynthesis · immune-hematologic · reproductive

Folate / one-carbon metabolism. Biosynthesis pathway. Folate (folic acid → DHF → THF) is reduced via DHFR — the methotrexate target. THF accepts one-carbon units…

Modulators

• methotrexate — inhibitor
• folic-acid — substrate
• methylfolate — substrate
• pyridoxine — cofactor

Sources: PMID:20608755