SAMe

metabolite · nervous · Oral · IV · Intramuscular

SAMe, a metabolite. Universal methyl donor for >100 methyltransferases — DNMT (DNA methylation), HMT (histones), COMT (catecholamine… Oral half-life 6.2 h.

Universal methyl donor for >100 methyltransferases — DNMT (DNA methylation), HMT (histones), COMT (catecholamine inactivation), GNMT (creatine synthesis), PEMT (phosphatidylcholine synthesis). Donates a methyl group to become S-adenosyl-homocysteine (SAH), then demethylated to homocysteine. SAMe/SAH ratio is the 'methylation potential.' Clinical antidepressant effect comparable to TCAs in some RCTs.

Pharmacokinetics

• Oral — t½ 6.2 h · F 3% · ka 0.2843 h⁻¹ · Vd 28 L
• IV — t½ 4.1 h · F 100%

Related compounds

• Methionine — synergistic
• L-Methylfolate — synergistic
• TMG (Betaine) — synergistic

Sources: PMID:19302903