TMG

metabolite · renal · Oral

TMG, a metabolite. Methyl donor to homocysteine via betaine-homocysteine methyltransferase (BHMT) — a B12-independent remethylation route parallel… Oral half-life 2 h.

Methyl donor to homocysteine via betaine-homocysteine methyltransferase (BHMT) — a B12-independent remethylation route parallel to methionine synthase. Complementary methyl donor for high-methylation-demand protocols (e.g., NMN → NAD⁺ → methylated nicotinamide). Also a renal osmolyte and a performance-enhancement ergogenic at ~2.5 g/d (mechanism uncertain — possibly via methyl support for creatine synthesis).

Pharmacokinetics

• Oral — t½ 2 h · F 85%

Related compounds

• Methionine — synergistic
• NMN — synergistic
• SAMe — synergistic
• Homocysteine — synergistic
• Creatine Monohydrate — synergistic
• Nicotinamide Riboside — synergistic

Sources: PMID:16365055