Creatine Monohydrate
Creatine Monohydrate, a metabolite. Endogenous guanidinoacetate derivative synthesised from arginine + glycine + methionine (via SAMe methyl… Oral half-life 3 h.
Endogenous guanidinoacetate derivative synthesised from Arginine + Glycine + Methionine (via SAMe methyl transfer). Stored in skeletal muscle + brain via the Creatine / phosphocreatine energy buffer system primarily as phosphocreatine (PCr). Creatine kinase catalyses PCr + ADP ↔ creatine + ATP — the phosphate shuttle that buffers ATP during high-turnover activity (5–10 s maximal efforts; brain cognitive load under sleep deprivation or hypoxia). Most extensively researched ergogenic agent; decades of consistent safety data across many populations including pediatric.
PK: THE STORED VOLUME WAS THE SOLVER DEFAULT WEARING A CITATION. 35 L is exactly 0.5 L/kg at the seventy-kilogram reference — the value resolvePk substitutes when the field is ABSENT — and this record cited abstract states no volume at all. Removing it is NUMERICALLY A NO-OP, since the resolver now supplies the identical number; what changes is that the record stops asserting a measurement it does not have, and the defaulted-volume lint begins counting it as the open gap it is. This is the batch-11 finding running backwards: there a deletion silently became a default, here a default had silently become a datum.
Pharmacokinetics
- Oral — t½ 3 h · F 99% · ka 0.9 h⁻¹
Related compounds
- TMG (Betaine) — synergistic
- Methionine — synergistic
Sources: PMID:28615996, PMID:12520625