Daidzein

flavonoid · digestive · Oral

Daidzein, a flavonoid. Isoflavone phytoestrogen — binds ER-β preferentially (10–20× over ER-α). Gut microbial conversion by Slackia… Oral half-life 7.8 h.

Isoflavone phytoestrogen — binds ER-β preferentially (10–20× over ER-α). Gut microbial conversion by Slackia isoflavoniconvertens / Adlercreutzia equolifaciens yields S-equol, the more active metabolite — only ~25–50% of adults are 'equol producers' depending on gut composition, which explains much of the clinical heterogeneity in soy studies.

PK: THE STORED VOLUME WAS THE SOLVER DEFAULT WEARING A CITATION. 35 L is exactly 0.5 L/kg at the seventy-kilogram reference — the value resolvePk substitutes when the field is ABSENT — and this record cited abstract states no volume at all. Removing it is NUMERICALLY A NO-OP, since the resolver now supplies the identical number; what changes is that the record stops asserting a measurement it does not have, and the defaulted-volume lint begins counting it as the open gap it is. This is the batch-11 finding running backwards: there a deletion silently became a default, here a default had silently become a datum.

Pharmacokinetics

• Oral — t½ 7.8 h · F 40% · ka 0.54 h⁻¹

Related compounds

• Genistein — synergistic

Sources: PMID:12672914