Genistein

flavonoid · digestive · immune-hematologic · Oral

Genistein, a flavonoid. Isoflavone phytoestrogen with ER-β preferential affinity. Also a tyrosine-kinase inhibitor at micromolar concentrations… Oral half-life 10 h.

Isoflavone phytoestrogen with ER-β preferential affinity. Also a tyrosine-kinase inhibitor at micromolar concentrations (basis for early anticancer interest) and a topoisomerase-II interactor. Gut microbiota metabolise genistein to dihydrogenistein and 6′-OH-O-desmethylangolensin; these metabolites vary widely between individuals.

PK: THE STORED VOLUME WAS THE SOLVER DEFAULT WEARING A CITATION. 35 L is exactly 0.5 L/kg at the seventy-kilogram reference — the value resolvePk substitutes when the field is ABSENT — and this record cited abstract states no volume at all. Removing it is NUMERICALLY A NO-OP, since the resolver now supplies the identical number; what changes is that the record stops asserting a measurement it does not have, and the defaulted-volume lint begins counting it as the open gap it is. This is the batch-11 finding running backwards: there a deletion silently became a default, here a default had silently become a datum.

Pharmacokinetics

• Oral — t½ 10.1 h · F 16% · ka 0.6181 h⁻¹

Related compounds

• Daidzein — synergistic

Sources: PMID:12672914