Dopamine

neurotransmitter · nervous · endocrine · IV

Dopamine, a neurotransmitter. catecholamine synthesis synthesised from tyrosine via L-DOPA (tyrosine hydroxylase, rate-limiting) → dopamine (AADC). Acts at dopamine…

Catecholamine synthesis synthesised from Tyrosine via L-DOPA (tyrosine hydroxylase, rate-limiting) → dopamine (AADC). Acts at Dopamine receptor signaling D1-like (D1, D5) and D2-like (D2, D3, D4) GPCRs. Nigrostriatal pathway → motor control; mesolimbic → reward; mesocortical → executive function; tuberoinfundibular → prolactin suppression. Depleted in Parkinson's (nigrostriatal loss).

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