Dopamine receptor signaling

receptor_pharmacology · nervous · endocrine · digestive

Dopamine receptor signaling. D1-D5. Receptor pharmacology pathway. Dopamine GPCRs split D1-family (D1, D5 — Gs-coupled, increase cAMP) and D2-family (D2, D3, D4 —…

Modulators

• levodopa — substrate
• aripiprazole — activator
• brexpiprazole — activator
• cariprazine — activator
• olanzapine — inhibitor
• quetiapine — inhibitor
• risperidone — inhibitor
• haloperidol — inhibitor
• clozapine — inhibitor
• metoclopramide — inhibitor

Sources: PMID:21303898