Fisetin

flavonoid · musculoskeletal · immune-hematologic · Oral

Fisetin, a flavonoid. Flavonol with senolytic activity — preferentially induces apoptosis in senescent cells via Bcl-2/Bcl-xL inhibition. Also… Oral half-life 3.1 h.

Flavonol with senolytic activity — preferentially induces apoptosis in senescent cells via Bcl-2/Bcl-xL inhibition. Also inhibits CD38 (NAD⁺ preservation), activates Nrf2 (antioxidant response), and reduces neuroinflammation (inhibits NF-κB and microglial activation). Strongest senolytic candidate among natural flavonoids in screens (Yousefzadeh 2018).

Pharmacokinetics

• Oral — t½ 3.1 h · F 5% · Vd 84 L

Related compounds

• Quercetin — synergistic

Sources: PMID:15113710