Quercetin

flavonoid · immune-hematologic · Oral

Quercetin, a flavonoid. Flavonol aglycone with mast-cell-stabilising activity (inhibits PLA2 + histamine release), nlrp3 inflammasome… Oral half-life 11 h.

Flavonol aglycone with mast-cell-stabilising activity (inhibits PLA2 + histamine release), NLRP3 inflammasome inflammasome suppression, and zinc-ionophore activity (shuttles Zn²⁺ across cell membranes, repurposed in early COVID protocols). CD38 inhibitor — preserves cellular NAD⁺ (see Niacin / NAD+ biosynthesis) by slowing its CD38-driven hydrolysis. Poorly bioavailable as aglycone; glucoside forms (rutin, isoquercitrin) have better absorption.

Pharmacokinetics

• Oral — t½ 11 h · F 2% · ka 6.737 h⁻¹ · Vd 98 L

Related compounds

• Zinc — synergistic
• Piperine — synergistic
• Fisetin — synergistic
• Rutin — synergistic
• Dasatinib — synergistic

Sources: PMID:11361045