Rutin

flavonoid · digestive · Oral

Rutin, a flavonoid. Rutinoside (rhamnose-glucose) of quercetin. Cannot be absorbed intact — requires colonic microbial α-rhamnosidase to liberate… Oral half-life 11 h.

Rutinoside (rhamnose-glucose) of quercetin. Cannot be absorbed intact — requires colonic microbial α-rhamnosidase to liberate quercetin-3-glucoside and then aglycone. Erlund 2000 showed Cmax of circulating quercetin after rutin is ~3× lower and Tmax 8× later than after equimolar quercetin aglycone, with terminal t½ ~11–28 h dominated by enterohepatic recycling of conjugates. All pharmacological activity in vivo is attributable to quercetin and its sulfate/glucuronide metabolites.

Pharmacokinetics

• Oral — t½ 11 h · F 2% · ka 0.15 h⁻¹ · Vd 98 L

Related compounds

• Quercetin — synergistic

Sources: PMID:11151743