GABA

neurotransmitter · nervous · Oral

GABA, a neurotransmitter. Principal inhibitory neurotransmitter in adult mammalian CNS. Agonist at GABA-A (ionotropic chloride channel → hyperpolarisation, the…

Principal inhibitory neurotransmitter in adult mammalian CNS. Agonist at GABA-A (ionotropic chloride channel → hyperpolarisation, the benzodiazepine target receptor family) and GABA-B (metabotropic). Synthesised from glutamate by GAD (pyridoxal-5'-phosphate cofactor). Exogenous GABA crosses the BBB minimally — anxiolytic effect claims often attributable to enteric / vagal signalling or placebo.

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