Glutamate

amino-acid · nervous · Oral

Glutamate, an amino acid. Principal excitatory neurotransmitter in CNS; acts at AMPA, NMDA, kainate (ionotropic) and mGluR1-8 (metabotropic) receptors. TCA cycle α-KG…

Principal excitatory neurotransmitter in CNS; acts at AMPA, NMDA, kainate (ionotropic) and mGluR1-8 (metabotropic) receptors. TCA cycle α-KG ↔ Glu transamination hub. Enterocytes oxidise dietary glutamate extensively — little reaches systemic circulation. Precursor to GABA via GAD.

Related compounds

• GABA — synergistic

Sources: PMID:10837313