Gonadorelin
Gonadorelin, a peptide. Native GnRH decapeptide. Pulsatile administration drives physiologic LH/FSH release; continuous administration… IV half-life 0.1 h.
Native GnRH decapeptide. Pulsatile administration drives physiologic LH/FSH release; continuous administration paradoxically suppresses via GnRH-R desensitisation (the principle behind GnRH-agonist therapy for prostate cancer, endometriosis, precocious puberty). Commonly used in TRT protocols at 100–200 mcg SC 2×/week to maintain testicular function.
PK: Pimstone 1977 (PMID:320223), normal subjects on constant IV infusion, states a RANGE rather than a value — verbatim "The t1/2 of the first component ranged from 5.5 to 8 min in normal subjects." The stored 0.11 h (6.6 min) is the midpoint of that range, kept because no scalar exists and recorded here so the spread is visible. Note it describes only the FIRST component: the same abstract says decay "was linear for 8-10 min, after which a much slower component was observed", so this value discards the slow phase. The paper also gives a metabolic clearance rate of 1640 +/- 59.7 mL/min.
Pharmacokinetics
- IV — t½ 7 min
Related compounds
- Testosterone Cypionate — synergistic
Sources: PMID:320223