Hesperidin

flavonoid · cardiovascular · digestive · Oral

Hesperidin, a flavonoid. Rutinoside (rhamnose-glucose) of the flavanone hesperetin. Cannot be absorbed intact — colonic microbial α-rhamnosidase +… Oral half-life 8 h.

Rutinoside (rhamnose-glucose) of the flavanone hesperetin. Cannot be absorbed intact — colonic microbial α-rhamnosidase + β-glucosidase cleave the sugar moieties, liberating hesperetin aglycone that is then glucuronidated in the enterocyte/liver and enters systemic circulation as conjugates (Tmax 5–7 h). Endothelium-directed effects are mediated by hesperetin conjugates: eNOS upregulation, lower ICAM-1/VCAM-1, modestly improved FMD in RCTs (Cochrane 2019).

Pharmacokinetics

• Oral — t½ 8 h · F 5% · ka 0.15 h⁻¹ · Vd 42 L

Related compounds

• Naringenin — synergistic

Sources: PMID:12571654