Naringenin

flavonoid · cardiovascular · digestive · Oral

Naringenin, a flavonoid. Flavanone aglycone; as naringin glycoside from grapefruit it is a well-characterised CYP3A4 and OATP1A2/2B1 inhibitor —… Oral half-life 2.3 h.

Flavanone aglycone; as naringin glycoside from grapefruit it is a well-characterised CYP3A4 and OATP1A2/2B1 inhibitor — the 'grapefruit juice effect' on statin and CCB pharmacokinetics. Activates PPARα (lipid oxidation) and inhibits ApoB secretion; LDL reduction in animal models.

Pharmacokinetics

• Oral — t½ 2.3 h · F 15% · Vd 56 L

Related compounds

• Hesperidin — synergistic

Sources: PMID:15113710