Modafinil
Modafinil, a stimulant. Weak DAT inhibitor (catecholamine synthesis); orexin arousal axis and histamine receptor pharmacology modulation. Oral half-life 13 h.
Weak DAT inhibitor (Catecholamine synthesis); Orexin / wakefulness arousal axis and Histamine receptor pharmacology modulation.
Prescription-only in most jurisdictions. Slow absorption; Tmax ~2-4h. DAT (dopamine transporter) occupancy is the primary mechanism per Volkow 2009 PET data: Ki ~2 µM = ~0.55 mg/L (modafinil MW 273). Therapeutic Cmax ~3-5 mg/L gives ~85-90% DAT occupancy — clinically informative range where the Hill curve is not yet at saturation. PK: THE STORED ABSORPTION RATE WAS THE SOLVER DEFAULT WEARING A CITATION. A ka of 1.0/h is exactly what resolvePk substitutes when the field is ABSENT, and no source on this record states one. Removing it is NUMERICALLY A NO-OP — the resolver supplies the identical number — so no curve moves; what changes is that the record stops asserting an absorption rate it never measured. This is the same shape already found on a volume of 35 L, which is likewise the default at the seventy-kilogram reference. THE WIDER DEBT IS LEFT ALONE ON PURPOSE: twelve values account for 152 of the 276 authored absorption rates, but the other eleven are NOT the default, so deleting those would move their curves rather than leave them, which is the error this audit spent a batch documenting.
Pharmacokinetics
- Oral — t½ 13 h · F 40% · Vd 60 L
Related compounds
- Hormonal contraceptives — major
- Omeprazole — caution
- Midazolam — caution
- Dextromethorphan — caution
Sources: PMID:9549666, PMID:12537513, PMID:29178272