Orexin / wakefulness arousal axis

receptor_pharmacology · nervous

Orexin / wakefulness arousal axis. Receptor pharmacology pathway. Lateral hypothalamic orexin (hypocretin) neurons project broadly to monoaminergic + cholinergic…

Modulators

• suvorexant — inhibitor
• lemborexant — inhibitor
• daridorexant — inhibitor
• modafinil — activator
• armodafinil — activator
• adrafinil — activator
• caffeine — activator
• adenosine — inhibitor
• ramelteon — activator
• tasimelteon — activator

Sources: PMID:17299454