Nicotine

stimulant · nervous · Oral · Sublingual · Transdermal · Inhaled

Nicotine, a stimulant. nicotinic ach receptor pharmacology agonist (α4β2, α7); releases acetylcholine, dopamine, norepinephrine. Oral half-life 4.3 h.

Nicotinic ACh receptor pharmacology agonist (α4β2, α7); releases Acetylcholine, Dopamine, Norepinephrine.

High addiction liability. Avoid nightly use.

Pharmacokinetics

• Oral — t½ 4.3 h · F 40% · ka 0.4 h⁻¹ · Vd 180 L
• Transdermal — t½ 4.5 h · F 76% · Vd 180 L
• Inhaled — t½ 4.3 h · F 53% · ka 10.63 h⁻¹ · Vd 180 L

Sources: PMID:19184644, PMID:9882698, PMID:3545615