Resveratrol

polyphenol · cardiovascular · endocrine · Oral

Resveratrol, a polyphenol. Direct nad sirtuin axis SIRT1 activator at high concentrations (disputed — some studies show fluorophore artifact).… Oral half-life 9 h.

Direct NAD+ / sirtuin / longevity axis SIRT1 activator at high concentrations (disputed — some studies show fluorophore artifact). Also activates AMPK energy sensor, inhibits PDE4, and is a weak ER-α ligand. Extensively glucuronidated + sulfated — plasma aglycone concentration is low even at gram doses. Commonly paired with NMN in 'longevity' stacks.

Pharmacokinetics

• Oral — t½ 9 h · F 1% · Vd 70 L

Related compounds

• NMN — synergistic
• Pterostilbene — synergistic

Sources: PMID:15333514