NAD+ / sirtuin / longevity axis

biosynthesis · endocrine · musculoskeletal

NAD+ / sirtuin / longevity axis. Biosynthesis pathway. NAD+ is the central redox + signaling cofactor whose tissue levels decline with aging. Synthesis routes: (1) de…

Modulators

• nmn — substrate
• nad-plus — substrate
• namn — substrate
• naad — substrate
• niacin — substrate
• resveratrol — activator
• pterostilbene — activator
• rapamycin — inhibitor
• metformin — activator
• spermidine — activator

Sources: PMID:26785480, PMID:28721271