L-Theanine

amino-acid · nervous · Oral

L-Theanine, an amino acid. Glutamate analog — crosses the BBB via LAT1. Increases α-wave EEG power (wakeful-relaxed state) and modulates gaba a… Oral half-life 1.2 h.

Glutamate analog — crosses the BBB via LAT1. Increases α-wave EEG power (wakeful-relaxed state) and modulates GABA-A receptor signaling and Glycine release. Partial Glutamate receptor pharmacology / AMPA + kainate glutamate receptor modulation receptor activity. Does not share glutamate's excitotoxic profile — dampens Caffeine's sympathetic overshoot without blunting its alertness effect.

Pharmacokinetics

• Oral — t½ 1.2 h · ka 1.8 h⁻¹ · Vd 56 L

Related compounds

• Caffeine — synergistic

Sources: PMID:23096008, PMID:18006208