Calcineurin / NFAT T-cell activation

signaling · immune-hematologic · cardiovascular · integumentary

Calcineurin / NFAT T-cell activation. Signaling pathway. Calcineurin (PP2B) is a Ca²⁺/calmodulin-dependent serine/threonine phosphatase — the canonical T-cell…

Modulators

• cyclosporine — inhibitor
• tacrolimus — inhibitor
• pimecrolimus — inhibitor
• rapamycin — inhibitor
• everolimus — inhibitor
• temsirolimus — inhibitor
• azathioprine — inhibitor
• methotrexate — inhibitor
• dexamethasone — inhibitor
• prednisone — inhibitor

Sources: PMID:32210952, PMID:10099825