PI3K / AKT signaling

signaling · endocrine · nervous · cardiovascular · immune-hematologic · musculoskeletal

PI3K / AKT signaling. insulin & growth factor. Signaling pathway. PI3K → AKT is the central insulin / growth factor transduction axis — distinct from mtor signaling…

Modulators

• insulin — activator
• semaglutide — activator
• tirzepatide — activator
• rapamycin — inhibitor
• everolimus — inhibitor
• temsirolimus — inhibitor
• metformin — inhibitor
• imatinib — inhibitor
• dasatinib — inhibitor
• nilotinib — inhibitor

Sources: PMID:17604717, PMID:28431241, PMID:28802037