5-HTP

amino-acid · nervous · Oral

5-HTP, an amino acid. Direct serotonin precursor (see serotonin melatonin axis); bypasses tryptophan hydroxylase. Oral half-life 2 h.

Direct Serotonin precursor (see Tryptophan → serotonin → melatonin); bypasses Tryptophan hydroxylase.

Do not combine with SSRIs/MAOIs.

Pharmacokinetics

• Oral — t½ 2 h · F 50% · Vd 80 L

Related compounds

• Tryptophan — synergistic
• Vitamin B6 — synergistic
• Serotonin — synergistic

Sources: PMID:9727088, PMID:18308795