(+)-Catechin
(+)-Catechin, a flavonoid. Free flavan-3-ol aglycone (2R,3S stereochemistry) — the (+)-enantiomer. Minor component of most flavan-3-ol sources… Oral half-life 2 h.
Free flavan-3-ol aglycone (2R,3S stereochemistry) — the (+)-enantiomer. Minor component of most flavan-3-ol sources compared with its stereoisomer (−)-epicatechin. Absorbed at the small-intestine enterocyte and extensively glucuronidated / sulfated / methylated (via COMT) before entering portal circulation; free catechin in plasma is <3% of total SRC conjugates. Carbohydrate co-ingestion boosts AUC ~2× (Schramm 2003); dairy protein reduces it. Shares antioxidant, mild eNOS-upregulating, and anti-inflammatory effects with epicatechin.
PK: THE STORED VOLUME WAS THE SOLVER DEFAULT WEARING A CITATION. 35 L is exactly 0.5 L/kg at the seventy-kilogram reference — the value resolvePk substitutes when the field is ABSENT — and this record cited abstract states no volume at all. Removing it is NUMERICALLY A NO-OP, since the resolver now supplies the identical number; what changes is that the record stops asserting a measurement it does not have, and the defaulted-volume lint begins counting it as the open gap it is. This is the batch-11 finding running backwards: there a deletion silently became a default, here a default had silently become a datum.
Pharmacokinetics
- Oral — t½ 2 h · F 15%
Related compounds
- Epicatechin — synergistic
- EGCG — synergistic
Sources: PMID:12798412