EGCG

flavonoid · immune-hematologic · Oral

EGCG, a flavonoid. Flavan-3-ol gallate ester — the dominant green-tea polyphenol. DNMT1 inhibitor (epigenetic demethylation), 20S proteasome… Oral half-life 3 h.

Flavan-3-ol gallate ester — the dominant green-tea polyphenol. DNMT1 inhibitor (epigenetic demethylation), 20S proteasome inhibitor (preclinical antineoplastic), COMT inhibitor (extends Catecholamine synthesis action — rationale for combined fat-oxidation protocols with Caffeine). Potent aqueous-phase antioxidant. Strongest iron-chelator among tea polyphenols (relevant for Fe²⁺ bioavailability reduction).

Pharmacokinetics

• Oral — t½ 3 h · F 1% · Vd 70 L

Related compounds

• Caffeine — synergistic
• Iron — caution
• (+)-Catechin — synergistic
• (−)-Epicatechin — synergistic

Sources: PMID:11205489