Caffeine demethylation

drug_metabolism · digestive

Caffeine demethylation. Drug metabolism pathway. Caffeine (1,3,7-trimethylxanthine) clears via three parallel N-demethylations by CYP1A2: N3-demethylation to…

Modulators

• fluvoxamine — inhibitor
• ciprofloxacin — inhibitor
• modafinil — activator
• theacrine — inhibitor
• mixed-amphetamine-salts — inhibitor
• bergamottin — inhibitor

Sources: PMID:8964416, PMID:2729942