Klotho / FGF23 phosphate axis

endocrine_axis · renal · endocrine · musculoskeletal

Klotho / FGF23 phosphate axis. Endocrine axis pathway. Klotho (αKlotho) is a single-pass transmembrane protein discovered as a longevity gene — Klotho-deficient mice…

Modulators

• cholecalciferol — substrate
• ergocalciferol — substrate
• calcitriol — activator
• calcipotriene — activator
• calcium — cofactor
• cinacalcet — activator
• atorvastatin — inhibitor
• rosuvastatin — inhibitor

Sources: PMID:30455427, PMID:32982966