LDL receptor + PCSK9 axis

transport · cardiovascular · digestive

LDL receptor + PCSK9 axis. Transport pathway. LDL receptor (LDL-R) clears circulating LDL particles by hepatic endocytosis. After internalization, LDL-R normally…

Modulators

• atorvastatin — activator
• rosuvastatin — activator
• ezetimibe — inhibitor
• cholestyramine — inhibitor
• colesevelam — inhibitor
• fenofibrate — activator
• gemfibrozil — activator
• icosapent-ethyl — activator
• bempedoic-acid — inhibitor
• evolocumab — inhibitor

Sources: PMID:28304224, PMID:30403574, PMID:19299327