Opioid receptor signaling

receptor_pharmacology · nervous

Opioid receptor signaling. MOR / KOR / DOR. Receptor pharmacology pathway. Gi/o-coupled GPCRs activated by endogenous opioid peptides (β-endorphin, enkephalins…

Modulators

• morphine — activator
• oxycodone — activator
• buprenorphine — activator
• nalbuphine — activator
• naloxone — inhibitor
• hydrocodone — activator
• codeine — activator
• hydromorphone — activator
• oxymorphone — activator
• fentanyl — activator

Sources: PMID:11152760, PMID:30792513