Platelet aggregation

signaling · immune-hematologic · cardiovascular

Platelet aggregation. ADP + TXA2 + GPIIb-IIIa. Signaling pathway. Three reinforcing activation loops. (1) Thromboxane A2 from platelet COX-1: aspirin irreversibly…

Modulators

• aspirin — inhibitor
• clopidogrel — inhibitor
• ticagrelor — inhibitor
• prasugrel — inhibitor
• dipyridamole — inhibitor
• cilostazol — inhibitor
• pentoxifylline — inhibitor

Sources: PMID:19717846, PMID:17982182