5-HT2A psychedelic signaling

receptor_pharmacology · nervous

5-HT2A psychedelic signaling. Receptor pharmacology pathway. The 5-HT2A receptor is a Gq-coupled GPCR expressed at high density on cortical layer V pyramidal neurons…

Modulators

• psilocybin — activator
• lsd — activator
• dmt — activator
• mdma — activator
• mescaline — activator
• trazodone — inhibitor
• mirtazapine — inhibitor
• risperidone — inhibitor
• olanzapine — inhibitor
• clozapine — inhibitor

Sources: PMID:26841800, PMID:37280397