Circadian clock

signaling · nervous · endocrine · cardiovascular · digestive · immune-hematologic

Circadian clock. BMAL1 / CLOCK / PER / CRY. Signaling pathway. The mammalian circadian clock is a transcription-translation feedback loop (TTFL) with ~24h period —…

Modulators

• melatonin — activator
• ramelteon — activator
• tasimelteon — activator
• agomelatine — activator
• suvorexant — inhibitor
• lemborexant — inhibitor
• daridorexant — inhibitor
• caffeine — inhibitor
• modafinil — inhibitor
• armodafinil — inhibitor

Sources: PMID:27990019, PMID:23916625, PMID:35577675