Mitophagy

cell_death · nervous · musculoskeletal · cardiovascular

Mitophagy. PINK1 / Parkin. Cell death pathway. Mitophagy — selective autophagy of damaged mitochondria — distinct from general macroautophagy (autophagy lc3 axis).…

Modulators

• rapamycin — activator
• everolimus — activator
• metformin — activator
• urolithin-a — activator
• nmn — cofactor
• nr — cofactor
• spermidine — activator
• resveratrol — activator
• quercetin — activator
• fisetin — activator

Sources: PMID:21179058, PMID:39358449