Cholesterol absorption + reverse transport

transport · cardiovascular · digestive

Cholesterol absorption + reverse transport. NPC1L1 uptake + HDL / ABCA1 efflux. Transport pathway. Distinct from cholesterol_synthesis (mevalonate / HMG-CoA reductase…

Modulators

• ezetimibe — inhibitor
• cholestyramine — substrate
• colesevelam — substrate
• niacin — activator
• niacinamide — substrate
• red-yeast-rice — inhibitor
• fish-oil — activator
• epa-dha — activator

Sources: PMID:26039521, PMID:22508840