p53 / MDM2 DNA-damage response

signaling · immune-hematologic · integumentary · nervous · reproductive

p53 / MDM2 DNA-damage response. Signaling pathway. p53 (TP53) is the "guardian of the genome" — a transcription factor that senses cellular stress (DNA damage…

Modulators

• rapamycin — activator
• metformin — activator
• curcumin — activator
• resveratrol — activator
• quercetin — activator
• egcg — activator
• luteolin — activator
• withaferin-a — activator
• sulforaphane — activator
• aspirin — activator

Sources: PMID:11747320