Parkinson disease

disease_cascade · nervous

Parkinson disease. α-synuclein aggregation. Disease cascade pathway. Parkinson disease (PD) progression centers on α-synuclein (SNCA) misfolding + aggregation in…

Modulators

• levodopa — substrate
• selegiline — inhibitor
• rasagiline — inhibitor
• rapamycin — inhibitor
• curcumin — inhibitor
• resveratrol — inhibitor
• egcg — inhibitor
• quercetin — inhibitor
• luteolin — inhibitor
• melatonin — inhibitor

Sources: PMID:30853581