Unfolded protein response / ER stress

signaling · immune-hematologic · digestive · endocrine · nervous

Unfolded protein response / ER stress. PERK / IRE1 / ATF6. Signaling pathway. The unfolded protein response (UPR) is the ER's quality-control system for accumulated…

Modulators

• metformin — inhibitor
• rapamycin — inhibitor
• aspirin — inhibitor
• curcumin — inhibitor
• resveratrol — inhibitor
• quercetin — inhibitor
• luteolin — inhibitor
• egcg — inhibitor
• dha — inhibitor
• epa — inhibitor

Sources: PMID:22013210